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簡要描述：U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM).
產(chǎn)品型號：abs810003廠商性質(zhì)：生產(chǎn)廠家更新時間：2024-07-07訪 問 量：1101產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | 純度 | >98% |
|---|---|---|---|
| 規(guī)格 | 5mg;10mg;25mg;50mg;100mg | 供貨周期 | 現(xiàn)貨 |
| 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,化工,生物產(chǎn)業(yè),制藥,綜合 |
描述：
U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.
純度：
>98%
儲存/保存方法：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
溫馨提示：本產(chǎn)品僅作科研實驗使用，不支持臨床等研究
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地址：上海市浦東新區(qū)新浩路58號申江科創(chuàng)園18棟
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